| MadSci Network: Molecular Biology |
Antibiotics (biotic meaning bacteria) are natural or synthesized chemicals which inhibit or block metabolism of critical biologica functions of bacteria. Bacteria are free-living organisms who must use metabolic processes to acquire nutrients, digest them and synthesize membranes, organelles, cell wall and capsule. Some or all of these components may be present in all bacteria including pathogenic ones. A lot of antibiotics affect cell wall or capsule synthesis and others effect synthesis of proteins or enzymes the bacteria need to live. Viruses, on the other hand, cannot continue living outside of the eukaryotic (animal, or plant) cells which they infect. Viruses must use the metabolic machinery of the host eukaryotic cell to replicate itself. Therefore, using a typical antibiotic rationale attempts to interfere with viral replication metabolism like described above for bacteria would make the host cells sick without necessarily harming the viruses. Since viruses are protein enveloped bits of DNA or RNA, most "antiviral" drugs are directed to metabolism of DNA or RNA but to be effective and safe these drugs must be targetted to DNA or RNA actions that are not normally used by the eukaryotic host cells. This is an extremely difficult task and many antiviral drugs make normal host cells pretty sick and there is an increased risk of serious (DNA/RNA) mutations, possibly leading to neoplasia that can result if antiviral drugs are used too much too long. http://www.soton.ac.uk/~gk/sc ifi/virals.htm http://www.scrip ps.edu/newsandviews/e_20020401/wong.html I hope this is what you were looking for. I was on vacation when your question came in.
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