Re: Do Proton pump inhibitors for acid reflux affect acid balance in the body?

You should also remember that the acid normally secreted by the 
stomach is later neutralized in the jejunum by the secretion of bicarbonate 
ion. So, if less acid is available, less bicarbonate is secreted. It all 
balances out. I am not aware of any other sites where the PPI's act. I have 
been unable to find mention of any after a short search on Google. The 
PPI's only work when the pH is around 4.  There are very few places in the 
body where that is the case. They irreversibly alter the H+/K+ ATPase in 
gastric parietal cells. The kidney is the only other organ I can think of 
that gets to that low a pH.

 The most common drug-induced acid-base problem is probably metabolic 
alkalosis caused by diuretic use.

Regards;
David.