Re: Why don't heat shock proteins denature?

Area: Biochemistry
Posted By: Markus Jaritz, Grad student Center for Applied Molecular Engineering
Date: Tue Jun 24 09:14:02 1997
Area of science: Biochemistry
ID: 862846492.Bc

Message:

Why some proteins withstand high temperatures and others don't is
a pressing question in current publications in structural biology.

At the moment, thermal stability seems to reflect from several 
physicochemical features of proteins, like :

Better hydrogen bonding
Better hydrophobic internal packing
enhanced secondary structure propensity
helix dipole stabilisation

and a lot more. There is no general rule on how to enhance the thermal
stability of proteins. One of the latest papers in this field is:

"Protein thermal stability, hydrogen bonds, and ion pairs" by Gerhard Vogt,
Stefanie Woell and Patrick Argos (J.Mol.Biol. 1997 269).

Best regards, Markus

Current Queue | Current Queue for Biochemistry | Biochemistry archives

Try the links in the MadSci Library for more information on Biochemistry.