MadSci Network: Molecular Biology

Subject: 2 different mRNA sizes for one gene

Date: Tue Oct 8 07:27:26 1996
Posted by: Richard Isbrucker
Grade level: grad
School/Organization: Dalhousie University
City: Halifax State/Province: Nova Scotia
Country: Canada
Area of science: Molecular Biology
Message ID: 844777646.Mb
I have noticed that some genes, such as those for collagen
types 1 and 3, produce two mRNA bands of different sizes on
northern blots.  This is well documented in research 
publications, but no paper has discussed the significance of
the two distinct mRNA products derived from a single gene.
The double mRNA is detected regardless if the nucleic acids 
were derived from total RNA or purified mRNA thereby 
eliminating the possibility of detecting homologous nuclear

My question is: are both of the RNA species detected true
messenger RNA? Or is one of them (presumably the one with 
higher molecular weight)an unprocessed, or immature, mRNA
that undergoes further processing into a more translatable

Thanks for your help,

Richard Isbrucker

Re:2 different mRNA sizes for one gene

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