|MadSci Network: Microbiology|
Check out this web site. Yes, It is true that this anti-microbial compound is often added to hand soap with some residual effects.
Triclosan is a broad-spectrum antibacterial/anti-microbial agent. It is manufactured in the U.S. by Ciba-Geigy, under their trade name Irgasan DP300, and by several other manufacturers outside of the U.S.. As a result of its bacteriostatic activity against a wide range of both gram-negative and gram-positive bacteria it has found increasing and recent popular use in personal care products, i.e.- toothpaste, deodorant soaps, deodorants, antiperspirants and body washes, detergents, dish washing liquids, cosmetics and anti-microbial creams, lotions and hand soaps. It is also used as an additive in plastics, polymers and textiles to give these materials antibacterial properties.
Triclosan is a diphenyl ether (bis-phenyl) derivative, known as either 2,4,4'-Trichloro-2'-hydroxydiphenyl ether or 5-Chloro-2-(2,4- dichlorophenoxy) phenol. It is related in structure to a number of bis- phenyl polychlorinated and bis-phenyl chlorophenol compounds. Due principally to the synthesis chemistry of polychloro diphenyl ethers and phenoxy phenols there is the potential for the formation of small amounts of unwanted trace by-products which are of concern. Beginning in the early 1970's and into the mid 1980's research revealed that phenoxy herbicides such as 2,4-D and 2,4,5-T (1,2,3), the major components of Agent Orange, the bactericide Hexachlorophene (4,5), various chlorophenols, i.e.- pentatchlorophenol, used in wood treatment (6), certain polychloro phenoxy phenols (7) and polychloro diphenyl ethers (8) and diphenyl ether herbicides (9) contained various low levels of polychlorinated dioxins and polychlorinated furans.
Consequently, since triclosan is by its chemical structure a polychloro phenoxy phenol it is possible that several polychlorodibenzo-p-dioxins (dioxins) polychloro-dibenzofurans (dibenzofurans) can be found in varying low level amounts, as synthesis impurities in triclosan. Their presence or absences is dependent upon the type and purity of the starting materials used to synthesize triclosan as well as reaction conditions such as temperature, pressure and the like. If present, their relative concentrations as impurities can vary from batch to batch. This raises concerns because of the toxicity of dioxins and dibenzofurans.
The toxicity of dioxins and dibenzofurans varies with the position and number of chlorine atoms attached to the aromatic rings. In general, their toxicity increases with increasing chlorine substitution. Those dioxins and dibenzofurans that have chlorine atoms at the 2,3 and 7 positions are particularly toxic. Tetrachlorodibenzo-p-dioxin and tetrachlorodibenzo- furan, which have chlorine atoms at the 2,3,7, and 8 positions, are considered the most toxic of the dioxins and dibenzofurans (4), with 2,3,7,8-tetrachlorodibenzo-p-dioxin referred to as one of the most toxic substances known.
As a result of the potential for the formation of dioxins and dibenzofurans as unwanted low level trace by-products the USP, in Pharmacopeial Form, Volume 22, Number 3, Pharmacopeial Reviews and subsequently in Pharmacopeial Form, Volume 23, Number 5, In-Process Revision, has proposed a new monograph for the specific testing of triclosan. This proposed monograph details the assay and testing of USP triclosan. In addition to setting product specification standards and procedures to assay the purity and physical identity of USP triclosan, it also defines the limits and methods of testing for unwanted trace by- products which may be present. The proposed tests for these unwanted by- products are (1) Limit of 4-Chlorophenol and 2,4-Dichloro-phenol, (2) Limit of Triclosan Related Compound A (1,3,7-trichlorodibenzo-p-dioxin), Triclosan Related Compound B (2,8-dichlorodibenzo-p-dioxin), 2,8- Dichlorodibenzofuran, and 2,4,8-Trichlorodibenzo-furan, and (3) Limit of 2,3,7,8-Tetra-chlorodibenzo-p-dioxin and 2,3,7,8-Tertrachloro- dibenzofuran.
Quantex Laboratories is one of the few laboratories in the U.S. capable of analyzing triclosan for dioxins and dibenzofurans employing isotope dilution high resolution gas chromatography/mass spectrometry (HRGC/MS), as required by the proposed USP monograph. For those requiring the testing and certification of triclosan as meeting the proposed USP limits for unwanted trace by-products Quantex Laboratories can perform the three limit tests:
Angela I. Parisi-Menoutis has over 24 years of experience in methods development and analysis of surfactants, quaternaries, amines, polyols, personal care products, specialty chemicals and intermediates. She spent 8 years as an R&D Group Leader with Lonza, Inc., and prior to that 7 years as an analytical chemist with Colgate Palmolive Company. Her background includes extensive expertise in mass spectral methods development and interpretation including analysis by isotope dilution HRGC/MS.
James Menoutis has over 20 years experience as an analytical chemist, group leader and manager. His experience includes toxicology, methods development and analysis of botanicals, flavors, fragrances, pharmaceuticals, analysis and methods development for the analysis of clinical pharmaceuticals, pesticide residue analyses, occupational health and toxicological analyses and environmental analytical methods. As a research analytical chemist with Givaudan were he researched dioxin and dibenzofuran chemistry in hexachlorophene and its raw materials. He has an extensive analytical background which includes experience in isotope dilution HRGC/MS.
Bonnie Tam adds:
Triclosan is an antibacterial added to soaps, dishwashing liquids, toothpastes, etc. FDA studies show that triclosan-fluoride paste prevent gingivitis, tartar and plaque better than fluoride-only toothpastes. Currently, the FDA has approved Colgate Total which contains triclosan as safe and effective for its intended use. http:// www.pharminfo.com/pubs/msb/triclos240.html
Medical professionals and other consumers have also used triclosan in wash products for over 30 years. Triclosan has controlled and reversed outbreaks of resistant bacteria infections in hospitals -- an environment where bacterial resistance is continually monitored. http://www.prnewswire.com/cgi-bin/stories.pl?ACCT= 104&STORY=/www/story/08-10-1998/0000729297&EDATE=
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