Re: How long does the affect of nicotine stay in a body

From: Goodman & Gilman, "The Pharmacological Basis of Therapeutics". 5th 
ed. Macmillan Publishing Co., New York. Nicotine is one of the most toxic 
of all drugs; it acts at a rate comparable to that of cyanide. The acute 
fatal dose is about 60 mg. It is a common natural insecticide spray.
	Nicotine, together with its detoxication products, is eliminated 
completely and rapidly by the kidney. The rate of urinary excretion of 
nicotine is dependent upon the pH of the urine; when the urine is alkaline, 
only one fourth as much nicotine is excreted as when the urine is acid. 
Thus, the diet of the animal, specifically the mineral and salt content, 
can have an effect on the acidity of the urine and the elimination of 
nicotine. A complete review of the literature that would include knowing 
the mineral intake with urinary acid changes and measurement of nicotine 
excretion in the animal used in this study should be done.