MadSci Network: Medicine
Query:

Re: Is Hodgkin's Disease cause any health hazards if left untreated?

Date: Mon Sep 21 13:01:01 1998
Posted By: Art Anderson, Mucosal Immunology, USA Medical Research Institute of Infectious Diseases
Area of science: Medicine
ID: 901461610.Me
Message:

I not sure I understand what the questioner is concerned about. 

Are they asking if Hodgkins will affect other people living in the 
environment of the patient (ie is it infectious), or are they asking if 
someone who has Hodgkins could survive without treatment?

There is no evidence to suggest that Hodgkins disease is infectious. 
Although some epidemiological studies show clusters of disease, no studies 
have given evidence of disease transmission. 

The behavior of the disease if left untreated is one that ultimately will 
result in the death of the patient as the lymphatic system is 
progressively taken over by the pleomorphic but characteristic cellular 
infiltrate. 

Many theories exist to explain Hodgkins pathogenesis but most see the 
"reticular" cells (Reed Sternberg Cells) as important controlling factors 
in its progression. 

Radiation and Chemotherapeutic Regimens have been developed that cause 
disease remission and improve survival to very good percentages.


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