MadSci Network: Biochemistry |
VX nerve gas {methylphosphonothioic acid S-[2- [bis(1-methylethyl)amino]ethyl] O-ethyl ester} has been around the media a bit lately because traces of it were allegedly found near a Sudanese pharmaceutical plant which prompted US forces to bomb it as a suspected chemical weapons plant. It was also featured in the movie 'The Rock' with Nicholas Cage and Sean Connery. Apparently one of Saddam Hussein's favourite accessories as well. It is popular with poorer nations and terrorist organisations because it is relatively easy to make, so long as you have the facilities to contain it. So in theory you could make it in the backyard, but it would be the last thing you do! VX belongs to a family of chemicals known as 'choline esterase inhibitors', others in this group include Sarin (used in a terrorist attack on the Tokyo subway), Tabun and the insecticide Parathion. In a nut-shell these compounds block enzymes called 'choline esterases' which are involved in the processes in the brain for communicating nerve impulses. So VX kills you by causing respiratory arrest by disrupting your brain's normal activity which most importantly controls breathing etc. An effective antidote is the muscle stimulant atropine. For an adult human, the leathal dose of either VX, Sarin or Tabun is less than 1mg (a single drop of water weighs about 50mg to give you some perspective). Most of the above information came from the Merck Index, 12th Edition and the text-book 'Biochemistry' 4th Edition by Lubert Stryer. If you really want to know about the exact mechanism of action on a molecular level then any university level Biochemistry text-book should have a section on 'acetyl choline' and 'choline esterase inhibitors' with diagrams For more information on the web you can go to VX or Sarin . Hope this is of some use. Dr. Scott Starling University of Sydney, Australia Starling@bigpond.com