MadSci Network: Medicine
Query:

Subject: Erythroblastosis Fetalis: communication between mother's and fetal blood

Date: Tue Aug 24 15:18:50 1999
Posted by Faisal Nahri
Grade level: undergrad School: Hamdard College of Medicine & Dentistry
City: Karachi State/Province: No state entered. Country: Pakistan
Area of science: Medicine
ID: 935522330.Me
Message:

1) In erythroblastosis for the mother's Rh- blood to receive RBCs from 
fetus Rh+ blood, there should be a communication thru the placenta i.e. 
thru the villi of the fetus projecting into the intervillous spaces in the 
placenta. There would be a flow of mother's blood cells into the fetal 
circulation also. Please confirm this!!

2) Why does the first baby have less chances to develop the disease than 
the subsequent children. The mother takes about 3 months to develop a good 
titer of antibodies; therefore if the communication occurs in the early 
2nd trimester the first baby should also have lot of chances to develop 
erythroblastosis fetalis! Is this early communication possible? Comment 
and please clear it

3) Only Ig-G antibodies can cross the placenta, this means that the Rh 
antibodies prepared by the mother are Ig-G. Confirm







Re: Erythroblastosis Fetalis: communication between mother's and fetal blood

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