MadSci Network: Molecular Biology
Query:

Re: After transcription takes place, what happens to the introns that were

Date: Thu Apr 8 12:38:41 1999
Posted By: Mark Woelfle, Faculty, Molecular Biology, Vanderbilt University
Area of science: Molecular Biology
ID: 923412195.Mb
Message:

So what happens to the excised introns after splicing?  Experiments have 
shown that for the majority of spliced genes the steady-state level of 
intron sequences in RNA preparations is about 10 times lower than exon 
sequences. This suggests that the excised introns are rapidly degraded in 
the cell after splicing. The intron sequences do not encode protein or 
serve any other useful function in the cell after being spliced. Degradation by 
enzymes called RNAses breakdown the intron RNA into it's ribonucleotide 
components for reuse in the cell.




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