MadSci Network: Zoology

Re: why does heart rate of daphnia change in the presence of an antioxidants+ c

Date: Wed Jan 26 08:00:27 2000
Posted By: Terry Hebert, Faculty, Universite de Montreal, Biochemistry, Montréal Heart Institute
Area of science: Zoology
ID: 948742730.Zo

Hello Xenia,

Caffeine first: This is from an answer I posted some time ago. Just like you, a daphnia’s heart will beat faster when it receives a dose of caffeine. Caffeine belongs to a class of compounds called methylxanthines and can block a receptor on the surface of heart muscle cells for adenosine. In fact, it is caffeine's blockade of the A1 adenosine receptor in the heart that causes the heart to pound after a significant caffeine dose. Caffeine and similar compounds also inhibit a class of enzymes known as cyclic nucleotide phosphodiesterases. These enzymes are, in part responsible for degrading a stimulatory signal produced when excitatory neurotransmitters activate different neurons in the central nervous system (CNS). Thus, when they are inhibited by caffeine, the stimulatory signal remains active for a longer period of time resulting in a greater sense of alertness (a CNS effect) but also a higher heart rate, blood pressure and respiratory rate.

As for vitamin C and Vitamin B. I couldn't find any reference to direct effects of vitamin B on heart rate in any species including daphnia or humans. I guess you'll have to do the experiment yourself. There are some reports that Vitamin C can increase heart rate. Vitmain C or ascorbic acid is an antioxidant, that is it prevents damage to cells via generation of free radicals. It is known that antioxidants can play a great role in protecting the heart from different kinds of diseases but the mechanisms are not well understood. Hope this helps, Terry

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