MadSci Network: Neuroscience |
Dear No Name Entered, So you are looking for the Holy Grail of prosthetics! I can guarantee it will be a long hard road, but one that needs smart, inventive people and the rewards could be fantastic. Since you are doing a report, I will try to find web sights that will give you valuable information as well as some of what I know off the top of my head, but I may not remember the source. First, the brain. An extremely complex organ that we still know little about. We do know that all brain signals are electric in nature and are therefore, theoretically, measurable. But it would be like marking a honey bee with a white dot and sending it into a hive and listening for it's buzz. Be pretty difficult with thousands of other buzzes occurring at the same time! Now if we knew the particular buzz our bee made and could filter out the rest and knew where our bee likes to hang out, the job would be easier. There is some work along this line that I know of. You may have heard about artificial eyes lately. The ones I know of work by small receptors that pick up hues and shades and are transmitted to small silicon chips that are formed in the shape of a small nail bed (or something similar. Imagine an array of sharp silicon spires on a small wafer). These are jabbed into the optical region of the brain, and each spire is connected to one receptor. When one receptor picks up color or light, it sends a signal to the spire which in turn activates a neuron ( or a couple of neurons) in the optic area of the brain. An array of receptors activates an array of spires which activate an array of neurons. The resulting image is like a very low resolution picture with some color and shading. (Think of what your monitor would look like with 20x20 pixel resolution instead of 600x800 or more!)Some of the problem is getting the receptors and electronics small enough, and the other is getting the silicon spires narrow enough. With the latest photoimaging processes you still are hitting a number of neurons with one spire. The other is getting them to the right neurons. There isn't a way to single out individual neurons, just areas. I tried to find some information on the talk that I had heard on the above info but found none. (The talk was really about micro-silicon part production, the eye thing was just an example). However, I did find three excellent articles on artificial retinas that focused on implanted chips that directly excite the ganglion of the optic nerve. (My above explanation was for optic nerve damaged patients). Again, there are problems with the fact that they still can't specify which ganglion they excite, and how many! The first three articles are on essentially the same concept, and the fourth is a very exciting hybrid implant using artificially cultured neuron cells! Probably the most advanced work in non-organic to nerve interaction is in retina development. http://www.optobionics.com/ http://www.coe .ncsu.edu/news.releases/liu.retina.html http://rleweb.mit.edu/retina/ http: //www.cmplx.cse.nagoya-u.ac.jp/research/retina/index.html Second, the nerves and external limbs. First off, I will take offense at your statement that "anyone can throw a few pipes together with pivot points and make it mobile with a small engine." As an ME I can assure you it is not that easy. Mobile power (batteries are heavy and run down quickly), strength vs. speed and how to control them, and realistic movement are all very complex engineering problems associated with electric arm design. But I will grant you, those are easier than what you are interested in doing! One of the best examples that I am familiar with is the Utah Arm, which was developed at the University of Utah. The idea of this arm was to use metal conductors and a signal amplifier to detect the electrical output from remnant muscles in the stump of the arm. This means that a mid-humerus amputation usually leaves some of the biceps and triceps muscles. These are still controlled by the amputee. Now just like the heart has an electrical signal that can be detected in an EKG, these muscles, when contracted, give of a small electrical signal. This is amplified by the metal receptors which turns on the appropriate motor for arm movement. Motion Control is the current manufacturer and the arm info can be found at http://www.utaharm.com// . It isn't a great sight but will give you some info and some good pictures and perhaps some links. Good luck with your report. I hope I shed some light what you were asking about. If you have physiology (how the body works) questions, you might need to reference some medical books (Fundamentals of Physiology: Second Edition by Lauralee Sherwood from West Publishing Co. is a great beginning book on how the body works. You librarian may know how to get it on loan for you). If you have more questions or would like to pick my brain about school, careers, etc. I would be very willing to talk to you about it as your goal is what I originally started out to do as well (and may still do!). E-mail me any time if you have questions at bradk@jymis.com. Again, best of luck and keep following your dream! BK
Try the links in the MadSci Library for more information on Neuroscience.