MadSci Network: Cell Biology |
Catalase, as you say, converts H2O2 into H2O and O2. H2O2, and other reactive oxygen species, are toxic in tissues (but sometimes beneficial as a defense agent) because they can irreversibly inactivate enzymes, damage DNA, proteins and lipids or alter the redox state of enzymes. See also: http://www.graylab.ac.uk/lab/reviews/pwrev.html http://www.accessexcellence.org/LC/ST/bgfreerad.html and the references therein. Catalase removes the H2O2 as soon as it forms, thereby protecting tissues from damage. This is especially important during fatty-acid metabolism where H2O2 is a by-product. The implications of H2O2 damage in human health are wide-ranging (see links above). Oxidative damage is thought to play a role in things such as premature aging, cancer, atherosclerosis and Lou Gehrig's Disease. There is much interest in preventing oxidative damage with 'antioxidants' such as vitamin C, vitamin E, beta-carotene and others which you may have heard about in the popular press.
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