MadSci Network: Cell Biology
Query:

Re: What effect does Catalase have upon the human body?

Date: Fri May 17 19:50:02 2002
Posted By: John R Engen, Faculty, Chemistry, biochemistry, molecular biology, University of New Mexico
Area of science: Cell Biology
ID: 1018698552.Cb
Message:

Catalase, as you say, converts H2O2 into H2O and O2.  H2O2, and other 
reactive oxygen species, are toxic in tissues (but sometimes beneficial as 
a defense agent) because they can irreversibly inactivate enzymes, damage 
DNA, proteins and lipids or alter the redox state of enzymes.

See also: http://www.graylab.ac.uk/lab/reviews/pwrev.html http://www.accessexcellence.org/LC/ST/bgfreerad.html
and the references therein.

Catalase removes the H2O2 as soon as it forms, thereby protecting tissues 
from damage.  This is especially important during fatty-acid metabolism 
where H2O2 is a by-product.

The implications of H2O2 damage in human health are wide-ranging (see links 
above).  Oxidative damage is thought to play a role in things such as 
premature aging, cancer, atherosclerosis and Lou Gehrig's Disease.  There 
is much interest in preventing oxidative damage with 'antioxidants' such as 
vitamin C, vitamin E, beta-carotene and others which you may have heard 
about in the popular press.


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