|MadSci Network: Immunology|
Hi there. In answer to the first question, I think that costimulatory blockade would be general, in that all T cells that were reacting at that time would be supressed. Experimentally of course, researchers tend to immunise and then measure the blocked response. But, I believe that costimulatory blockade would downregulate the responses going on at that particular time. Anergy would be the most probable outcome. As for the second question, I'm not aware of any cytokines that cause tolerance on their own. TGF-B and IL-10 cause downregulation of T cell responses and are involved in T cell tolerance. Then again, so are some other cytokines like IFN gamma. There may be some papers around but if there are, they would be using a particular model that I haven't come across.
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