Re: 2questions. 1)does costimulatory blockade make the body more prone to

Hi there.

In answer to the first question, I think that costimulatory blockade would 
be general, in that all T cells that were reacting at that time would be 
supressed.  Experimentally of course, researchers tend to immunise and 
then measure the blocked response.  But, I believe that costimulatory 
blockade would downregulate the responses going on at that particular 
time.  Anergy would be the most probable outcome.

As for the second question, I'm not aware of any cytokines that cause 
tolerance on their own.  TGF-B and IL-10 cause downregulation of T cell 
responses and are involved in T cell tolerance.  Then again, so are some 
other cytokines like IFN gamma.  There may be some papers around but if 
there are, they would be using a particular model that I haven't come 
across.