MadSci Network: Immunology
Query:

Subject: Can the murine FC receptor on Natural Killer cells bind human FC

Date: Fri Jun 24 17:10:49 2005
Posted by steve
Grade level: undergrad School: u of Penn
City: philadelphia State/Province: pa Country: usa
Area of science: Immunology
ID: 1119651049.Im
Message:

Wondering if you could access the ADCC potential of a human antibody in a 
mouse.  To do this the FC receptor on the murine NK cells will need to bind 
the human antibody via it's FC chain.   (murine antibody will typically bind 
to murine NK cells and induce ADCC).    Thanks for the help!


Re: Can the murine FC receptor on Natural Killer cells bind human FC

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