MadSci Network: Development |
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The major (normal) cause of changes in facial features with aging is the resorption of bone (see this review by Mendelson & Wong. 2012). Bone is typically built by osteocytes (derived from osteoblasts) and resorbed by osteoclasts. [Wikipedia]. When their action is in balance (homeostasis), the bone is stable. The activity of these cells is regulated by a number of secreted factors [see Bonewald, 2012]. With aging, the bone-building activity of osteocytes decreases, and there is a net
decrease (resorption) of bone: the arrows in this figure (←) point to the major sites of
resporption (from Mendelson & Wong). |
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