| MadSci Network: Cell Biology |
That's an excellent question.
You are right that animal cells are more complex than bacterial cells. Animal cells
have more DNA. This DNA is present in multiple linear pieces in animal cells,
whereas bacterial cells have a single circular piece of DNA. In addition, animal
cells have structures called organelles, responsible for unique tasks required for
cell survival. The amount of DNA and the division of labor by organelles
contributes to the complexity of animal cells.
It is precisely the increased complexity that gave rise to the different replication
processes used by animal cells and bacterial cells. While the biochemical process
of replicating the DNA is very similar in animal cells and bacterial cells, the
mechanical processes of segregating the DNA and intracellular components are
different. For the bacterial cell, as the DNA is replicated, the original DNA and the
new copy are attached to the plasma membrane. As the bacterial cell grows the
two DNAs are separated because the plasma membrane between them expands.
The septum (a new piece of plasma membrane) grows between the two
chromosomes and eventually divides the cell in two.
The simple replication and division (called binary fission) of bacterial cells would
not work for animal cells. Why not? First, the DNA material in animal cells is
separated from the rest of the cell by a double membrane, so the DNA cannot
readily become attached to the plasma membrane. Second, in an animal cell there
are many chromosomes. In a human for example, there are 46 chromosomes.
There would not be sufficient plasma membrane to which to attach in an organized
fashion all of the chromosomes and their copies. Third, because the animal cell
has so many chromosomes, it must have a mechanism for keeping track of each
chromosome and its copy to make sure each daughter cell gets one each of the
chromosomes. During mitosis (animal cell division) a spindle apparatus is formed.
The spindle apparatus looks like two bicycle wheels right next to each other with
the spokes of the two wheels connected in the center of the cell. These spokes
protrude into the center of the cell and become associated with the chromosomes.
{Each bicycle wheel eventually corresponds to a daughter cell.} The association of
the spokes with the chromosomes allows one copy of each chromosome to be
moved to each daughter cell. Fourth, each daughter cell must not only inherit a
copy of each chromosome, but also receive appropriate amounts of organelles.
During the process of animal cell replication and division, the DNA and organelles
are replicated then apportioned to the daughter cells.
The process of animal cell division (mitosis) is quite well understood on a
molecular level and well-documented using fluorescence microscopy. To get more
details about mitosis, check out a basic cell biology textbook like Essential Cell
Biology by Alberts and others (Garland Science). Happy reading!
Try the links in the MadSci Library for more information on Cell Biology.