MadSci Network: Genetics |
The following is from the Open Door website which discusses sickle cell anemia. This disorder is caused by a defect in hemoglobin the protein which carries oxygen in the blood. Heterozygotes for the condition are more resistant to malaria and that is why this condition is thought to have some selective benefit in evolutionary terms. Hope this helps Gabriel Vargas, md/phd GENETICS CO-DOMINANCE Not all genes have dominant and recessive alleles. Some have alleles that are both expressed together in the heterozygote individuals. Co-dominant alleles have three phenotypes, one for each genotype. In humans there are a number of conditions that are co-dominant. Sickle cell anaemia is a genetic disease that affects the hemoglobin of the red blood cells. Hemoglobin is normally a ball-shaped molecule but the sickle cell allele makes it form long strands. The red blood cell carrying these molecules distorts into characteristic long shapes. The shape of the hemoglobin molecule is controlled by two alleles Normal Hemoglobin allele and the Sickle Cell Hemoglobin allele There are three phenotypes: Normal individuals have two normal hemoglobin alleles Sickle cell anemia, a severe form where all the red blood cells are affected. Sickle cell anemia patients have two sickle cell alleles in their genotype Sickle cell trait, a mild condition where 50% of the red blood cells are affected. Sickle cell trait individuals are heterozygotes, having one of each allele. Reference: http://www.s aburchill.com/IBbiology/chapters03/004.html Medical encyclopedia from NIH on Sickle Cell http://ww w.nlm.nih.gov/medlineplus/ency/article/000527.htm
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