| MadSci Network: Cell Biology |
Chromosomes only become distinct during prophase of the cell cycle; does that mean that they do not exist before prophase? Does DNA begin to supercoil around its associated histone proteins prior to prophase, or just during prophase? What is the physical state of DNA molecules prior to prophase? I've heard that DNA molecules are in a diffused state called chromatin in the nucleus prior to cell division. But what exactly is chromatin? As I understand it, chromatin is a substance of diffuse DNA molecules and histone proteins. Are the DNA molecules actually attached to the histone proteins before prophase/the beginning of cell division? Has a DNA-protein complex already been formed at this point? Does the DNA-histone complex perhaps form as soon as DNA molecules are formed from DNA replication during S phase of interphase? When then does the supercoiling of the DNA and histones begin? Also, I've heard conflicting statements about the number of DNA molecules in a chromosome. Is it 1 or 2? If it's 2, is it because there is 1 DNA molecule in each chromatid of the chromosome? Thank you very much. I am very grateful for any help you may be able to offer me.
Re: Do chromosomes exist before prophase of the cell cycle?
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