| MadSci Network: Medicine |
Okay, let me make clear that this is a specialised question, that the BBB isn't my speciality, and I haven't spent that much time looking at this issue.
Caveats aside, the normal warning for high penetration across the BBB is
lipophilicity, and domperidone has that. However, domperidone is also a
substrate for P-glycoprotein. Hence, the theory would be that PGP causes
rapid excretion of the compound from the BBB.
http://www.medscape.com/viewarticle/409741_4
domperidone lipophilicity here:
http://www.pnas.org/cgi/reprint/91/1/68.pdf
It seems there is a lot of literature on this, and I can't imagine you will have difficulty searching. There are pgp null mice, people have expressed the pgp in cells, and there are inhibitors of pgp available.
yours
david
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